Wang Group
July 20224
A manuscript entitled 'Chemoenzymatic Synthesis of Sulfated N-Glycans Recognized by Siglecs and Other Glycan-Binding Proteins' was accepted by JACS Au.
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​Congratulations to Kun and other co-workers!
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May 20224​
Natasha Owitipana and Helena Yun have successfully passed their candidacy exams.
Congratulations to Natasha and Helena!
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March 20224​
Dr. Diksha Rai has joined the Wang research group as a postdoctoral fellow.
We welcome Dr. Diksha Rai to our lab!
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February 20224​
Yuxin Wang has joined the Wang research group as a PhD student in the Biochemistry PhD program.
We welcome Yuxin to our lab!
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December 20223
* Dr. Wang has been elected to the National Academy of Inventors’ (NAI) 2023 Class of Fellows.
https://cmns.umd.edu/news-events/news/dinesh-manocha-lai-xi-wang-national-academy-inventors
Congratulations to Dr. Wang!
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*Dr. Jinghua Han has joined the Wang research group as a postdoctoral fellow.
We welcome Dr. Jinghua Han to our lab!
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October 20223
Grace Lunde successfully passed her PhD thesis defense.
Congratulations to Dr. Lunde!
July 20223
Dr. Wang was named Distinguished University Professor of the University of Maryland.
Congratulations to Dr. Wang!
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June 20223
Thomas Connor Donahue successfully passed his PhD thesis defense.
Congratulations to Dr. Donahue!
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April 2022​
Chong Ou successfully passed his PhD thesis defense.
Congratulations Dr. Ou!
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11/21/2021
A manuscript entitled 'Chemoenzymatic Synthesis and Antibody Binding of HIV-1 V1/V2 Glycopeptide-Bacteriophage Qβ Conjugates as a Vaccine Candidate' was accepted by Int J Mol Sci.
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Congratulations to Guanghui and other co-workers!
11/3/2021
Sunaina Prabhu successfully defended her PhD thesis.
Congratulations to Dr. Prabhu!
09/27/2021
A manuscript entitled 'General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody-Drug Conjugates' was accepted by ACS Chem Biol.
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Congratulations to Xiao and other co-workers!
08/19/2021
A manuscript entitled 'Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game' was accepted by Chem Sci.
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Congratulations to Xiao and other co-workers!
08/05/2021
A manuscript entitled 'One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling' was accepted by Bioconjug Chem.
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Congratulations to Chong and other co-workers!
06/10/2021
A manuscript entitled 'A facile chemoenzymatic synthesis of SARS-CoV-2 glycopeptides for probing glycosylation functions' was accepted by Chem Commun.
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Congratulations to Guanghui and other co-workers!
05/25/2021
A manuscript entitled 'Comparative studies on the substrate specificity and defucosylation activity of three α-l-fucosidases using synthetic fucosylated glycopeptides and glycoproteins as substrates' was accepted by Bioorg Med Chem.
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Congratulations to Sunaina and other co-workers!
05/12/2021
A manuscript entitled 'Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its Fcγ Receptor Affinity and ADCC Activity' was accepted by J Am Chem Soc.
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Congratulations to Chao and other co-workers!
May 2021
Dr. Wang won the Norma M. Allewell Prize in Entrepreneurship, from the University of Maryland College Park.
Congratulations to Dr. Wang!
03/17/2021
A manuscript entitled 'Appropriate aglycone modification significantly expands the glycan substrate acceptability of α1,6-fucosyltransferase (FUT8)' was accepted by Biochem J.
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Congratulations to Roushu and other co-workers!
01/16/2021
A manuscript entitled 'Exploring a combined Escherichia coli-based glycosylation and in vitro transglycosylation approach for expression of glycosylated interferon alpha' was accepted by Bioorg Med Chem.
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Congratulations to Sunaina and other co-workers!
11/2/2020
Roushu Zhang successfully defended her PhD thesis.
Congratulations to Dr. Zhang!
09/15/2020
A manuscript entitled 'Exploring a combined Escherichia coli-based glycosylation and in vitro transglycosylation approach for expression of glycosylated interferon alpha' was accepted by Bioorg Med Chem.
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Congratulations to Yuanwei and other co-workers!
May 2020
Dr. Wang Won the Dean’s Award of Excellence in Teaching, from the College of Computer, Mathematical, and Natural Sciences (CMNS), University of Maryland College Park
Congratulations to Dr. Wang!
01/03/2020
A book chapter entitled 'Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens' was accepted by Methods in Molecular Biology.
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Congratulations to Guanghui and other co-workers!
6/4/2019
Xin (Claude) Tong successfully defended his PhD thesis.
Congratulations to Dr. Xin Tong!
11/5/2018
A manuscript entitled 'Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody.' was accepted by Proceedings of the National Academy of Sciences of the United States of America.
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Congratulations to John and the co-workers!
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11/1/2018
A manuscript entitled 'Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-dependent Antibodies with Promiscuous Site Recognition.' was accepted by Journal of Medicinal Chemistry.
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Congratulations to Hui and the co-workers!
9/11/2018
A book chapter entitled 'Chemoenzymatic Defucosylation of Therapeutic Antibodies for Enhanced Effector Functions Using Bacterial α-Fucosidases.' was published by Methods in Molecular Biology.
Congratulations to Chao and the co-workers!
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8/24/2018
A manuscript entitled 'Chemoenzymatic Methods for the Synthesis of Glycoproteins' was accepted by Chemical Reviews.
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Congratulations to Chao and the co-workers!
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8/13/2018
A manuscript entitled 'Generation and Comparative Kinetic Analysis of New Glycosynthase Mutants From Streptococcus pyogenes Endoglycosidases For Antibody Glycoengineering' was accepted by Biochemistry.
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Congratulations to Claude (Xin Tong) and the co-workers!
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6/8/2018
A manuscript entitled 'The Odd "RB" Phage-Identification of Arabinosylation as a New Epigenetic Modification of DNA in T4-Like Phage RB69' was accepted by Viruses.
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5/23/2018
A manuscript entitled 'Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine' was accepted by ACS Central Science.
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Congratulations to Hui and the co-workers!
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5/14/2018
A manuscript entitled 'Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S' was accepted by Nature Communications.
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5/8/2018
A manuscript entitled 'Top-Down Chemoenzymatic Approach to Synthesizing Diverse High-Mannose N-Glycans and Related Neoglycoproteins for Carbohydrate Microarray Analysis' was accepted by Bioconjugate Chemistry.
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Congratulations to Christian and the co-workers!
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3/22/2018
A manuscript entitled 'Site-specific immobilization of endoglycosidases for streamlined chemoenzymatic glycan remodeling of antibodies' was accepted by Carbohydrate Research.
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Congratulations to Kevin (Tiezheng Li) and the co-workers!
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1/31/2018
A manuscript entitled 'Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies.' was accepted by International Journal of Molecular Sciences.
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10/27/2017
A manuscript entitled 'Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses' was accepted by Cell Chemical Biology.
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Congratulations to Hui and the co-workers!
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10/09/2017
A manuscript entitled 'Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins' was accepted by Journal of the American Chemical Society.
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Congratulations to Chao and the co-workers!
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8/5/2017
An invited book chapter entitled 'Chemoenzymatic Glycan Remodeling of Natural and Recombinant Glycoproteins' was published on Methods in Enzymology.
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Congratulations to Qiang and the co-workers!
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7/29/2017
A manuscript entitled 'One-pot enzymatic glycan remodeling of a therapeutic monoclonal antibody by endoglycosidase S (Endo-S) from Streptococcus pyogenes' was accepted by Bioorganic & Medicinal Chemistry.
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Congratulations to Claude (Xin Tong) and the co-workers!
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7/20/2017
A manuscript entitled 'Revisiting the substrate specificity of mammalian α1,6-fucosyltransferase (FUT8) reveals that it catalyzes core fucosylation of N-glycans lacking α1,3-arm GlcNAc' was accepted by Journal of Biological Chemistry.
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Congratulations to Qiang and the co-workers!
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4/28/2017
A manuscript entitled 'Glycan Remodeling of Human Erythropoietin (EPO) Through Combined Mammalian Cell Engineering and Chemoenzymatic Transglycosylation' was accepted by ACS Chemical Biology.
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Congratulations to Qiang and the co-workers!
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4/25/2017
A manuscript entitled 'Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies' was accepted by Chem. Comm.
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Congratulations to Hui and the co-workers!
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4/18/2017
A manuscript entitled 'Systematic Synthesis and Binding Study of HIV V3 GlycopeptidesReveal the Fine Epitopes of Several Broadly Neutralizing Antibodies' was accepted by ACS Chemical Biology.
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Congratulations to Jared, Hui and the co-workers!
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3/24/2017
John Giddens successfully defended his PhD thesis.
Congratulations to Dr. John Giddens!
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3/15/2017
A manuscript entitled 'Modulating IgG effector function by Fc glycan engineering' was accepted by Proc. Natl. Acad. Sci.
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Congratulations to Kevin (Tiezheng Li) and the co-workers!
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2/5/2017
An invited book entitled 'Chemical Biology of Glycoproteins' (editor: Prof. Zhongping Tan and Prof. Lai-Xi Wang) was published by Royal Society of Chemistry.
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2/5/2017
An invited book chapter entitled 'Chemical Biology of Protein N-Glycosylation' was published on Chemical Biology of Glycoproteins by Royal Society of Chemistry.
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Congratulations to Chao and the co-workers!
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2/1/2017
Christian Toonstra successfully defended his PhD thesis.
Congratulations to Dr. Christian Toonstra!
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12/1/2016
An invited book chapter entitled 'Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates' was published on Advances in Carbohydrate Chemistry and Biochemistry by Academic Press.
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Congratulations to Chao and the co-workers!
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8/10/2016
A manuscript entitled 'Chemoenzymatic Synthesis and Receptor Binding of Mannose-6-Phosphate (M6P)-Containing Glycoprotein Ligands Reveal Unusual Structural Requirements for M6P Receptor Recognition' was accepted by J. Am. Chem. Soc.
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Congratulation to Takahiro and the co-workers!
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6/10/2016
A manuscript entitled 'Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling' was accepted by the Journal of Biological Chemistry.
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Congratulation to Kevin (Tiezheng) and the co-workers!
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5/22/2016
A manuscript entitled Mammalian α-1,6-Fucosyltransferase (FUT8) Is the Sole Enzyme Responsible for the N-Acetylglucosaminyltransferase I-independent Core Fucosylation of High-mannose N-Glycans.' was accepted by the Journal of Biological Chemistry.
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Congratulation to Qiang and the co-workers!
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5/22/2016
A manuscript entitled Mammalian α-1,6-Fucosyltransferase (FUT8) Is the Sole Enzyme Responsible for the N-Acetylglucosaminyltransferase I-independent Core Fucosylation of High-mannose N-Glycans.' was accepted by the Journal of Biological Chemistry.
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Congratulation to John and the co-workers!
Events
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2017 Carbohydrates Gordon Research Conference (GRC) will be held on June 25-30 in Mount Snow, West Dover, VT. Dr. Wang will be the chair of this conference.
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2017 NIH glycoscience day will be held on May, 5th in Natcher Conference Center, NIH.
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2017 the 253rd American Chemical Society Meeting will be held on April, 2-6 in San Francisco, CA.
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Our lab will celebrate the Chinese New Year of the Rooster at 12:30 PM on 1/27/17, in Room 3507, Chemistry Bldg (091). We warmly welcome our friends and colleagues to join us!
