Principal Investigator - Professor Lai-Xi Wang

Dr. Wang received his PhD in organic chemistry from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. After postdoctoral studies at Johns Hopkins University in glycobiology and Massachusetts Institute of Technology (MIT) in biochemistry and molecular biology, he joined the faculty of Institute of Human Virology, University of Maryland School of Medicine as a Tenure-Track Assistant Professor in 2000, promoted to Associate Professor with tenure in 2005, and to Full Professor with tenure in 2009 at University of Maryland School of Medicine. He was also a professor in the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine from 2007-2015. In 2015, he was recruited to University of Maryland College Park as Professor of Chemistry and Biochemistry to lead efforts in developing new research programs centered on chemical biology.
Dr. Wang was the recipient of the 2004 Young Investigator Award in Carbohydrate Chemistry and the 2014 Melville L. Wolfrom Award, both from the American Chemical Society. He was inducted into the prestigious Johns Hopkins University Society of Scholars in 2009 and was elected as AAAS Fellow in 2014. Dr. Wang’s professional service to the research communities includes serving as a member of the Editorial Advisory Board of Carbohydrate Research; a chartered member of the NIH Synthetic and Biological Chemistry (SBCA) Study Section (2008-2012); the Vice Chair of the 2015 Gordon Research Conferences on Carbohydrates; the Chair of the 2017 Gordon Research Conferences on Carbohydrates; and the Chair of the Division of Carbohydrate Chemistry, the American Chemical Society (2016). Dr. Wang was elected as an American Chemical Society Fellow (ACS Fellow) in 2019.

Current members
Dr. Zong received his Ph.D. degree in Chemistry at China Agricultural University in 2012, where he was trained as carbohydrate chemist. He then moved to University of Arkansas as a Research Associate working on medicinal chemistry and chemical proteomics of anticancer natural glycoresins. He joined Dr. Wang's group in 2018, works on the chemoenzymatic synthesis of natural and synthetic Nodulation Factors, HIV-1/SARS-CoV-2 N-glycopeptides for glycan function studies and vaccine development, antibody glycan remodeling, as well as Novel ADC platform development.


Dr. Xianyang Wang
Postdoctoral Fellow
Xianyang Wang received his Ph.D. degree in medicinal chemistry from Fudan University in 2022. He joined the Wang lab in the Spring of 2023. His research is to design and synthesize fluorinated and other functionalized oligosaccharides and glycans, then use a chemoenzymatic method to transfer them to antibody to make selectively modified antibody glycoforms, which will be used for probing antibody structure and functions.

Dr. Jinghua Han
Postdoctoral Fellow
Jinghua Han obtained his Ph.D. in Chemical Biology from Nankai University, Tianjin, China. He pursued postdoctoral research at Georgia State University in 2019, focusing on synthesizing Polysaccharides and Glycopeptides for antigen screening. In December 2023, he joined Dr. Wang’s group, where he is involved in the design and synthesis of fluorinated glycans and glycopeptides to optimize immunogens for vaccine development.

Dr. Diksha Rai
Postdoctoral Fellow
Diksha Rai completed her doctoral studies on the total synthesis of rare sugar-containing complex oligosaccharides from Indian Institute of Technology Bombay, India. She has also worked on the synthesis of antileishmanial compounds during her internship at the Central Drug Research Institute (CDRI) while pursuing her master's degree. In the spring of 2024, Diksha started working in Dr. Wang's lab, where she is focussing on a synthesis of various fluorinated glycans, which are valuable tools for metabolic oligosaccharide engineering (MOE) and immunological evaluation.

Darnell Harris
Graduate Student
Darnell earned his bachelor’s degree in biochemistry from Ithaca College in 2019. While there, he studied in two labs, one of which investigated the properties of a protein-carbohydrate based double-network gel excreted by a slug native to upstate New York, and the other which attempted to utilize protein crystallography to elucidate the structure of various bacterial enzymes. He also interned at the Nation Institute of Standards and Technology (NIST), working on protein structure studies via Cryo-EM. Darnell joined the Wang Lab in the Spring of 2020 and primarily focuses on antibody Fc sialylation.


Margaryta Gomozkova
Graduate Student
Margaryta obtained her Bachelor of Science degree in Biochemistry from Brigham Young University-Idaho in Rexburg, ID in the Spring of 2020. To expand her research experience, she worked as a research assistant in Palladin Institute of Biochemistry in Kyiv, Ukraine. She studied the reciprocal influence of isolated extracellular vesicles on cell responses associated with EMT/MET (cell adhesion, migration, and invasion). She joined Dr. Wang’s lab in the Spring of 2021.

Dilani Natasha Owitipana
Graduate Student
Natasha graduated with Bachelor of Science Honors in Biochemistry and Molecular Biology from University of Colombo, Sri Lanka, where her research focused on developing an antagonist for the S1P3 receptor. After graduation she worked as an assistant lecturer in the Department of Chemistry, UOC for a period of one year. She joined Wang’s lab in the Fall of 2022. Her work focuses on developing chemoenzymatic approaches in glycan remodeling. She loves to spend her free time with her friends and is big on keeping fit.



Helena Yun
Graduate Student
Helena received her Bachelor of Science in Chemistry with a specialization in Biochemistry at the University of Virginia in Charlottesville, Virginia in the Spring of 2022. There she worked on the synthesis of visible light photocatalysts for asymmetric catalysis in Dr. Lin Pu’s lab. She joined the Wang Lab in Fall of 2022 and is currently working on developing chemoenzymatic methods for site-specific antibody conjugation.

Nikolai Tolstoy
Graduate Student
Nikolai Tolstoy graduated with a BS in chemistry from the University of Pennsylvania in 2004. He did undergraduate research in the lab of Dr. Madeleine Joullie focusing on natural product synthesis. After graduating he worked in industry at Astra Zeneca, Phizer, and contract research organizations doing medicinal chemistry and formulation work. He then worked in clinical research in trauma and emergency medicine before returning to basic science and chemistry at UMD. He joined Dr. Wang’s lab in 2022 to work on the synthesis of antibody-drug conjugate.

Yuxin Wang
Graduate Student
Yuxin received her Bachelor's degree in Biochemistry from SUNY Binghamton University in 2023. There she worked as a research assistant in Dr. Guo's lab and focused on development of biosensors" for environmental pesticides detection. To expand her research experience, She got the internship in summer 2022 to work in the neuroscience lab at University of Minnesota, where she worked with in vitro study of mutation induced Tau protein mislocation. She joined Dr. Wang’s lab in the Spring of 2024 and is working on developing chemoenzymatic synthesis of glycopeptide.
